Yazar "Şensoy, Özge" için listeleme
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Catalytically competent non-transforming H-RASG12P mutant provides insight into molecular switch function and GAP-independent GTPase activity of RAS
Metehan, İlter; Şensoy, Özge (Nature Publishing Group, 2019)RAS mutants have been extensively studied as they are associated with development of cancer; however, H-RASG12P mutant has remained untouched since it does not lead to transformation in the cell. To the best of our knowledge, ... -
Computational approaches in antibody-drug conjugate optimization for targeted cancer therapy
Melo, Rita; Lemos, Agostinho; Preto, Antonio Jose; Almeida, Jose Guilherme; Correia, Joao D. G.; Şensoy, Özge; Moreira, Irina Sousa (Bentham Science Publishers Ltd, 2018)Cancer has become one of the main leading causes of morbidity and mortality worldwide. One of the critical drawbacks of current cancer therapeutics has been the lack of the target-selectivity, as these drugs should have ... -
Computational investigation and modulation of structural and functional properties of proteins for therapeutic purposes
Mansoor, Samman (İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2021)Proteins are dynamic molecules which undergo certain conformational changes to perform specific functions when needed in the cell. To have a holistic understanding of the conformational ensemble they attain one needs to ... -
Computational studies of G protein-coupled receptor complexes: Structure and dynamics
Şensoy, Özge; Almeida, Jose G.; Shabbir, Javeria; Moreira, Irina S.; Morra, Giulia (Elsevier Academic Press Inc, 2017)G protein-coupled receptors (GPCRs) are ubiquitously expressed transmembrane proteins associated with a wide range of diseases such as Alzheimer's, Parkinson, schizophrenia, and also implicated in in several abnormal heart ... -
Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro
Ferreira, Juliana C.; Fadl, Samar; İlter, Metehan; Pekel, Hanife; Rezgui, Rachid; Şensoy, Özge; Rabeh, Wael M. (John Wiley and Sons Inc, 2021)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ... -
Experimental and computational investigation of clustering behavior of cyclodextrin-perfluorocarbon inclusion complexes as effective histotripsy agents
Kaymaz, Betül; Mustafa, Waleed; Hall, Sarah; Vlaisavljevich, Eli; Şensoy, Özge; Yüksel Durmaz, Yasemin (American Chemical Society, 2022)Recently developed nanocones (NCs), which are inclusion complexes that are made up of cyclodextrins (CDs) and perfluorocarbons (PFCs), have shown promising results in nanoparticle-mediated histotripsy (NMH) applications ... -
FbpA iron storage and release are governed by periplasmic microenvironments
Şensoy, Özge; Atılgan, Ali Rana; Atılgan, Canan (Royal Society of Chemistry, 2017)Ferric binding protein (FbpA) is part of an elaborate iron piracy mechanism evolved in Gram-negative bacteria, shuttling iron in the periplasmic space, from the outer to the cytoplasmic membrane side. We address how the ... -
A GIPC1-palmitate switch modulates dopamine drd3 receptor trafficking and signaling
Arango-Lievano, Margarita; Şensoy, Özge; Borie, Amelie; Corbani, Maithe; Guillon, Gilles; Sokoloff, Pierre; Weinstein, Harel; Jeanneteau, Freddy (Amer Soc Microbiology, 2016)Palmitoylation is involved in several neuropsychiatric and movement disorders for which a dysfunctional signaling of the dopamine D3 receptor (Drd3) is hypothesized. Computational modeling of Drd3's homologue, Drd2, has ... -
In silico analysis of a highly mutated gene in cancer provides insight into abnormal mRNA splicing: Splicing factor 3B subunit 1k700e mutant
Samy, Asmaa; Süzek, Barış Ethem; Özdemir, Mehmet Kemal; Şensoy, Özge (MDPI AG, 2020)Cancer is the second leading cause of death worldwide. The etiology of the disease has remained elusive, but mutations causing aberrant RNA splicing have been considered one of the significant factors in various cancer ... -
In silico phosphorylation-independent activation of arrestin-3 protein by means of small molecules
Kurt, Mehmet Hanifi (İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)G protein-coupled receptors (GPCRs) are responsible for communication of the cell with its surroundings. Upon ligand binding, a set of conformational changes occurs at the GPCR, which triggers activation and dissociation ... -
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
İlter, Metehan; Kaşmer, Ramazan; Jalalypour, Farzaneh; Atılgan, Canan; Topçu, Ozan; Karakaş, Nihal; Şensoy, Özge (NLM (Medline), 2022)Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational ... -
Inhibition of SARS-CoV-2 main protease: A repurposing study that targets the dimer interface of the protein
Pekel, Hanife; İlter, Metehan; Şensoy, Özge (Taylor and Francis Ltd., 2022)Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread and lethality rates of the COVID-19 have ignited studies that focus on the development ... -
Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target
Ferreira, Juliana C.; Khrbtli, Abdul Rahman; Shetler, Cameron L.; Mansoor, Samman; Ali, Liaqat; Şensoy, Özge; Rabeh, Wael M. (American Society for Biochemistry and Molecular Biology Inc., 2021)Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 ... -
Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase
Pekel, Hanife; Güzel, Mustafa; Şensoy, Özge (Wiley, 2022)Farnesyltransferase (FTase) is a heterodimeric enzyme, which catalyzes covalent attachment of the farnesyl group to target proteins, thus coordinating their trafficking in the cell. FTase has been demonstrated to be highly ... -
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
Mansoor, Samman; Kayık, Gülru; Durdağı, Serdar; Şensoy, Özge (Elsevier B.V., 2022)Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ... -
Modulation of protein-protein interactions for the development of effective therapeutics - from a joint perspective of experiment and computation
Moreira, Irina Sousa; Şensoy, Özge (Bentham Science Publishers B.V., 2018)Many proteins present in living organisms act as obligate oligomers – that is to say - they require other protein partners to function properly. Oligomerization does not only lead to the formation of physical interactions, ... -
A new ratio-metric pH probe, "ThiAKS Green" for live-cell pH measurements
Akyol, Ali; Baykal, Doruk; Akdağ, Akın; Şensoy, Özge; Son, Cağdaş Devrim (Springer, 2023)Deviation of the H+ concentration from optimum values within the organelles is closely associated with irregular cellular functions that cause the onset of various diseases. Therefore, determining subcellular pH values in ...